Basic information of RIGI :

Official Symbol of Gene	RIGI
Species	Homo sapiens
Entrez Gene ID	23586
Official Full Name	RNA sensor RIG-I
Also known as	RIG1; DDX58; RIG-I; RLR-1; SGMRT2
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000107201 MIM:609631; AllianceGenome:HGNC:19102
Map Location	9p21.1

Sample information of multiple sclerosis:

Detected Sample	Peripheral blood
Sample Detail	N/A
Detected Method	Real-time PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	30 new cases of MS (22 females and 8 males) and 35 healthy controls (25 females and 10 males)

Literature information of multiple sclerosis :

Pubmed ID	32311159
Year	2020
Title	The effect of IFN-β 1a on expression of MDA5 and RIG-1 in multiple sclerosis patients

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	Thus, it seems that IFN-β 1a not only decreased pathogenic inflammatory responses but also modulated the expression of RIG-1 to protect the patients from infectious diseases and upregulation of IFN-I in a positive feedback
Mechanism/Pathway	Melanoma differentiation-associated protein 5 (MDA5) and retinoic acid-inducible gene 1 (RIG-1) are two critical pathogen recognition receptors (PRRs), which detect intracytoplasmic intracellular dsRNA [10–13]. MDA5 and RIG-1 use the same pathway; they both use interferon promoter stimulator 1 (IPS1) to activate two important transcription factors including interferon regulatory transcription factor 3 (IRF3) and nuclear factor-kappa B (NF-κB)