Basic information of HDAC1 :
| Official Symbol of Gene | HDAC1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3065 |
| Official Full Name | histone deacetylase 1 |
| Also known as | HD1; RPD3; KDAC1; GON-10; RPD3L1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000116478 MIM:601241; AllianceGenome:HGNC:4852 |
| Map Location | 1p35.2-p35.1 |
Sample information of multiple sclerosis:
| Detected Sample | Pooled cell suspensions of lymph nodes and spleens |
| Sample Detail | CD4t T cells |
| Detected Method | PCR |
| Disease | EAE |
| Disease subtype | N/A |
| Population | Cd4-Cre mice |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 28964722 |
| Year | 2017 |
| Title | A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Treatment risk |
| Result | EAE susceptibility was restored in WT:HDAC1-cKO mixed BM chimeric mice, indicating a cell-autonomous defect. Our data demonstrate a novel pathophysiological role for HDAC1 in EAE and provide evidence that selective inhibition of HDAC1 might be a promising strategy for the treatment of MS |
| Mechanism/Pathway | HDAC1-cKO CD4t T cells |
