Basic information of MYD88 :
| Official Symbol of Gene | MYD88 |
| Species | Homo sapiens |
| Entrez Gene ID | 4615 |
| Official Full Name | MYD88 innate immune signal transduction adaptor |
| Also known as | WM1; IMD68; MYD88D |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000172936 MIM:602170; AllianceGenome:HGNC:7562 |
| Map Location | 3p22.2 |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 19758186 |
| Year | 2009 |
| Title | T oll-like Receptors in Multiple Sclerosis Mouse Experimental Models |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | The role of individual TLR, in particular TLR3, TLR4, and TLR9, signaling in modulation of EAE inflammation varies with the experimental model employed and the immune cells that drive pathology. The TLR-dependent production of proinflammatory cytokines is regulated by mechanisms that dampen the pathway and prevent excess damage. Development of TLR antagonists to treat autoimmune diseases must acknowledge the possibility of interference with regulatory mechanisms |
| Mechanism/Pathway | TLR3 |
