Basic information of EBI3 :
| Official Symbol of Gene | EBI3 |
| Species | Homo sapiens |
| Entrez Gene ID | 10148 |
| Official Full Name | Epstein-Barr virus induced 3 |
| Also known as | IL27B; IL35B; IL-27B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000105246 MIM:605816; AllianceGenome:HGNC:3129 |
| Map Location | 19p13.3 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 29740452 |
| Year | 2018 |
| Title | interleukin-27 gene Therapy Prevents the Development of autoimmune encephalomyelitis but Fails to attenuate established inflammation due to the expansion of cD11b+gr-1+ Myeloid cells |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | We found that mice with established EAE had significant expansion of CD11b+Gr-1+ cells, and AAV-IL-27 treatment further expanded these cells and induced their expression of Th17-promoting cytokines such as IL-6. Adoptive transfer of AAV-IL-27-expanded CD11b+Gr-1+ cells enhanced EAE development. Thus, expansion of CD11b+Gr-1+ cells provides an explanation for the resistance to IL-27 therapy in mice with established disease |
| Mechanism/Pathway | IL-27 (AAV-IL-27) |
