Basic information of CD226 :

Official Symbol of Gene	CD226
Species	Homo sapiens
Entrez Gene ID	10666
Official Full Name	CD226 molecule
Also known as	PTA1; DNAM1; DNAM-1; TLiSA1
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000150637 MIM:605397; AllianceGenome:HGNC:16961
Map Location	18q22.2

Sample information of multiple sclerosis:

Detected Sample	Peripheral blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	C57BL/6
Sample Size	n = 5–6 mice group

Literature information of multiple sclerosis :

Pubmed ID	26359290
Year	2015
Title	Multiple sclerosis associated genetic variants of CD226 impair regulatory T cell function

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	Therefore, by combining human and mouse analyses we show that CD226 exhibits an important role in the activation of regulatory T cells, with its genetically imposed dysregulation impairing regulatory T cell function.
Mechanism/Pathway	affects CD4 + FOXP3 + Treg cells in their suppressive capacity