Basic information of RAG1 :
| Official Symbol of Gene | RAG1 |
| Species | Homo sapiens |
| Entrez Gene ID | 5896 |
| Official Full Name | recombination activating 1 |
| Also known as | RAG-1; RNF74 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000166349 MIM:179615; AllianceGenome:HGNC:9831 |
| Map Location | 11p12 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 and C57BL/6-CD45 |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 15735653 |
| Year | 2005 |
| Title | Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | In mice, CD11c+ DCs alone are sufficient to present antigen in vivo to primed myelin-reactive T cells in order to mediate CNS inflammation and clinical disease development. |
| Mechanism/Pathway | We confirmed the presence of DCs at the blood-brain barrier and meninges in mice, and analogous CD209+ cells were found in noninflamed human brain tissue, suggesting that initial antigen presentation could potentially occur at the blood-brain barrier, thus promoting entry of T cells into the CNS |
