Basic information of IL10 :

Official Symbol of Gene	IL10
Species	Homo sapiens
Entrez Gene ID	3586
Official Full Name	interleukin 10
Also known as	CSIF; TGIF; GVHDS; IL-10; IL10A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000136634 MIM:124092; AllianceGenome:HGNC:5962
Map Location	1q32.1

Sample information of multiple sclerosis:

Detected Sample	splenocyte suspensions
Sample Detail	N/A
Detected Method	PCR
Disease	EAE
Disease subtype	N/A
Population	N/A
Sample Size	n = 5–6 mice group

Literature information of multiple sclerosis :

Pubmed ID	21728174
Year	2011
Title	TGF-β signaling via smad4 drives IL-10 production in effector Th1 cells and reduces T cell trafficking in EAE

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	this study demonstrates that IL-10 reduced encephalitogenic markers such as IFN-γ and Tbet on Th1 effector cells expressing the IL-10R, but also prevented recruitment of both transferred and host-derived inflammatory T cells. These data establish a regulatory mechanism by which highly activated Th1 effector cells modulate their pathogenicity through induction of IL-10
Mechanism/Pathway	TGF-β signaling caused binding of smad4 to the IL-10 promoter