Basic information of HLA-DRB4 :

Official Symbol of Gene	HLA-DRB4
Species	Homo sapiens
Entrez Gene ID	3126
Official Full Name	major histocompatibility complex, class II, DR beta 4
Also known as	DR4; DRB4; HLA-DRB; HLA-DR4B; HLA-DRB4*
Gene Type	protein coding
dbXrefs	HGNC:HGNC:4952
Map Location	6p21.3

Sample information of multiple sclerosis:

Detected Sample	Peripheral blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	13cases/13controls

Literature information of multiple sclerosis :

Pubmed ID	10653315
Year	1999
Title	Cytokine production in patients carrying multiple sclerosis-linked HLA-DR alleles

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	We found normal levels of TNFα production by in vitro activated HLA-DR3+ and HLA-DR2+ lymphoid cells; in contrast, HLA-DR4+ MS patients produced significantly higher amounts of TNFα than healthy controls, and DR3+ and DR2+ patients. IFNγ, IL-10, and IL-4 levels did not differ significantly between the three groups of patients.
Mechanism/Pathway	TNF alleles reside within the class III region of the MHC and may be considered as candidate genes when studying HLA-linked MS susceptibility. The substitution of guanine (TNF1 allele) with adenosine (TNF2 allele) at position –308 of the polymorphic TNFα promoter region has been found to induce in vitro hyperproduction of TNFα from activated lymphoid cells [2, 14]. Although in contradiction to this, some authors suggest that HLA alleles associated with MS [3, 15], insulin-dependent diabetes mellitus [12], and systemic lupus erythematosus [6] may play a role of marker of linkage with polymorphic alleles predisposing to TNFα hyperproduction, raising the strong possibility that mononuclear cell cytokine production is controlled by the MHC genotype.