Basic information of IL17 :
| Official Symbol of Gene | IL17 |
| Species | Homo sapiens |
| Entrez Gene ID | 3605 |
| Official Full Name | interleukin 17A |
| Also known as | IL17; CTLA8; IL-17; ILA17; CTLA-8; IL-17A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000112115 MIM:603149; AllianceGenome:HGNC:5981 |
| Map Location | 6p12.2 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | T cell line |
| Detected Method | Real-time PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 31068940 |
| Year | 2019 |
| Title | CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-κB and STAT3 Transcription Factors on the Proximal Promoter |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | pSTAT3 and RelA/NF-κB Cooperate to Trans-activate the Human IL-17A Promoter in CD28-stimulated CD4+ T Cells |
| Mechanism/Pathway | a novel mechanism by which human CD28 may amplify IL-17A expression in human T lymphocytes and provide biological bases for immunotherapeutic approaches targeting CD28-associated class 1A PI3K to dampen IL-17A-mediated inflammatory response in autoimmune/inflammatory disorders. |
