Basic information of TET2 :

Official Symbol of Gene	TET2
Species	Homo sapiens
Entrez Gene ID	54790
Official Full Name	tet methylcytosine dioxygenase 2
Also known as	MDS; IMD75; KIAA1546
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000168769 MIM:612839; AllianceGenome:HGNC:25941
Map Location	4q24

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	peripheral blood mononuclear cells
Detected Method	qPCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	40 subjects (not receiving disease modifying therapies) with definite MS and 40 healthy volunteers

Literature information of multiple sclerosis :

Pubmed ID	24735979
Year	2014
Title	TET2 gene expression and 5-hydroxymethylcytosine level in multiple sclerosis peripheral blood cells

Results of multiple sclerosis :

Expression	down-regulated
Risk type	Disease risk
Result	We show that TET2 and DNMT1 expression is significantly down-regulated in MS PBMCs and it is associated with aberrant methylation of their promoters.
Mechanism/Pathway	Furthermore, 5hmC is decreased in MS PBMCs, probably as a result of the diminished TET2 level.