Basic information of GZMB :
| Official Symbol of Gene | GZMB |
| Species | Homo sapiens |
| Entrez Gene ID | 3002 |
| Official Full Name | granzyme B |
| Also known as | C11; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000100453 MIM:123910; AllianceGenome:HGNC:4709 |
| Map Location | 14q12 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | TH1/17, TH17, and DN cells |
| Detected Method | qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 29150604 |
| Year | 2017 |
| Title | Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulated |
| Risk type | Disease risk |
| Result | We find that TH1/17 cells have elevated expression of CXCR3 and reduced expression of IFNG, CCL3, CLL4, GZMB, and IL10 compared to healthy controls. |
| Mechanism/Pathway | N/A |
