Basic information of MIR484 :
| Official Symbol of Gene | MIR484 |
| Species | Homo sapiens |
| Entrez Gene ID | 619553 |
| Official Full Name | microRNA 484 |
| Also known as | MIRN484; mir-484; hsa-mir-484 |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000283736 miRBase:MI0002468; AllianceGenome:HGNC:32341 |
| Map Location | 16p13.11 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood mononuclear cells |
| Detected Method | RT-qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | MS clinic of kasr al ainy hospital- faculty of medicine-Egypt |
| Sample Size | 34 RRMS patients and 34 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 35030371 |
| Year | 2022 |
| Title | Apoptotic protease activating factor-1 gene and MicroRNA-484: A possible interplay in relapsing remitting multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulated |
| Risk type | Disease risk |
| Result | APAF-1 mRNA was significantly downregulated in patients whereas miR-484 expression was upregulated compared to controls. |
| Mechanism/Pathway | miR-484 is a negative regulator of APAF-1 and concluded that increased miR-484 could suppress apoptosis by targeting APAF-1 |
