Basic information of IL6ST :
| Official Symbol of Gene | IL6ST |
| Species | Homo sapiens |
| Entrez Gene ID | 3572 |
| Official Full Name | interleukin 6 cytokine family signal transducer |
| Also known as | CD130; GP130; HIES4; IMD94; STWS2; CDW130; HIES4A; HIES4B; IL-6RB; sGP130 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000134352 MIM:600694; AllianceGenome:HGNC:6021 |
| Map Location | 5q11.2 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | qPCR |
| Disease | MS |
| Disease subtype | PPMS,RRMS,SPMS |
| Population | Spanish |
| Sample Size | 54 primary progressive (PP), 70 relapsingremitting (RR), and 4 secondary progressive (SP) |
Literature information of multiple sclerosis :
| Pubmed ID | 35111166 |
| Year | 2022 |
| Title | Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55- IL6ST Gene Region in Immature Dendritic Cells |
Results of multiple sclerosis :
| Expression | down-regulated |
| Risk type | Disease risk |
| Result | In moDC, increased ANKRD55 gene expression was observed in PP MS patients compared to HC(p < 0.05), as well as decreased IL6ST expression in both PP MS and RR+SP MS groups. |
| Mechanism/Pathway | N/A |
