Basic information of MIR330 :
| Official Symbol of Gene | MIR330 |
| Species | Homo sapiens |
| Entrez Gene ID | 442902 |
| Official Full Name | microRNA 330 |
| Also known as | MIRN330; mir-330; hsa-mir-330 |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000284544 miRBase:MI0000803; AllianceGenome:HGNC:31771 |
| Map Location | 19q13.32 |
Sample information of multiple sclerosis:
| Detected Sample | PBMC |
| Sample Detail | N/A |
| Detected Method | RT-qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 60 MS patients / 30 healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 36043408 |
| Year | 2022 |
| Title | Study of The Correlation between miR-106a, miR-125b, and miR-330 on Multiple Sclerosis Patients by Targeting TNFSF4 and SP1 in NF-кb/TNF-α Pathway: A Case-Control Study |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | miR-330-5p is up-regulated in RRMS patients. |
| Mechanism/Pathway | The association of miRNA with components of the RNA-induced silencing complex (RISC) results in the degradation or translational repression and/or destabilization of their relevant mRNA.It occurs through miRNA binding to the 3′-untranslated region (UTR) of target genes.Growing evidence has shown the abnormal miRNA activity in CNS glial cells of patients with MS and peripheral blood immune cells compared with normal individuals, suggesting that miRNA expression could be correlated with MS pathogenesis and immunological features.The biological role of miR330-5p has been offered in some cells and cancers. MicroRNA-330 suppresses cell motility by decreasing the expression of Sp1, which plays the role of a transcription factor through the TNF-α pathway. |
