Basic information of TNFSF4 :

Official Symbol of Gene	TNFSF4
Species	Homo sapiens
Entrez Gene ID	7292
Official Full Name	TNF superfamily member 4
Also known as	GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TNLG2B
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000117586 MIM:603594; AllianceGenome:HGNC:11934
Map Location	1q25.1

Sample information of multiple sclerosis:

Detected Sample	PBMC
Sample Detail	N/A
Detected Method	RT-qPCR
Disease	MS
Disease subtype	RRMS
Population	Iranian
Sample Size	60 MS patients / 30 healthy subjects

Literature information of multiple sclerosis :

Pubmed ID	36043408
Year	2022
Title	Study of The Correlation between miR-106a, miR-125b, and miR-330 on Multiple Sclerosis Patients by Targeting TNFSF4 and SP1 in NF-кb/TNF-α Pathway: A Case-Control Study

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	TNFSF4 expression was increased significantly in recurrence and patients two months after relapse compared with healthy .
Mechanism/Pathway	OX40L is recognized as a ligand for OX40, also known as tumor necrosis factor ligand superfamily member 4 (TNFSF4) and CD252 (Cluster of differentiation 252), and is a type II transmembrane protein that might have a pivotal role in the differentiation and stimulation of T-cells.TNFSF4 is mainly expressed on the surface of T-cell antigen-presenting cell (APC) cells.The encoded protein of this gene is primarily expressed on activated CD4+ and CD8+ T-cells and various B-cells, microglia, vascular endothelial cells, and dendritic cells.The encoded protein is involved in APC interactions and facilitates the adhesion of T-cells to endothelial cells.Interaction between TNFSF4 and CD4+ T-cells by TNFSF4 stimulates nuclear factor-kappa B (NF-κB) through TNF-R related TRAF1 and TRAF2.Besides, this signaling pathway is related to several immune functional activities, which include the intensification of Th2 responses and the production of Th2 and Th1 cytokines.