Basic information of MIR125B1 :
| Official Symbol of Gene | MIR125B1 |
| Species | Homo sapiens |
| Entrez Gene ID | 406911 |
| Official Full Name | microRNA 125b-1 |
| Also known as | MIRN125B1; mir-125b-1 |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000207971 MIM:610104; miRBase:MI0000446; AllianceGenome:HGNC:31506 |
| Map Location | 11q24.1 |
Sample information of multiple sclerosis:
| Detected Sample | PBMC |
| Sample Detail | N/A |
| Detected Method | RT-qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 60 MS patients / 30 healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 36043408 |
| Year | 2022 |
| Title | Study of The Correlation between miR-106a, miR-125b, and miR-330 on Multiple Sclerosis Patients by Targeting TNFSF4 and SP1 in NF-кb/TNF-α Pathway: A Case-Control Study |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Data demonstrated that miR-125b was significantly diminished in both recurrence and two months after relapse patients and probably plays an essential role in RRMS patients. |
| Mechanism/Pathway | The association of miRNA with components of the RNA-induced silencing complex (RISC) results in the degradation or translational repression and/or destabilization of their relevant mRNA.It occurs through miRNA binding to the 3′-untranslated region (UTR) of target genes.Growing evidence has shown the abnormal miRNA activity in CNS glial cells of patients with MS and peripheral blood immune cells compared with normal individuals, suggesting that miRNA expression could be correlated with MS pathogenesis and immunological features.MiR125b was demonstrated to bind the 3′UTR of TNF-α. |
