Basic information of COX5B :

Official Symbol of Gene	COX5B
Species	Homo sapiens
Entrez Gene ID	1329
Official Full Name	cytochrome c oxidase subunit 5B
Also known as	COXVB
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000135940 MIM:123866; AllianceGenome:HGNC:2269
Map Location	2q11.2

Sample information of multiple sclerosis:

Detected Sample	PBMC
Sample Detail	N/A
Detected Method	RT-PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	30 MS patients / 30 healthy subjects

Literature information of multiple sclerosis :

Pubmed ID	23901189
Year	2013
Title	Investigation of cytocrom c oxidase gene subunits expression on the Multiple sclerosis

Results of multiple sclerosis :

Expression	down-regulation
Risk type	Disease risk
Result	Decreased gene expression COX5B was observed in MS patients comparison with normal subjects.
Mechanism/Pathway	The final respiratory chain complex (complex IV or cytochrome c oxidase [COX]) is the site at which over 90% of oxygen is consumed.There is a common symptom of MS with mitochondrial diseases such as (AD), (PD) and also the point mutation mtDNA can cause damage to the myelin.