Basic information of NR4A2 :

Official Symbol of Gene	NR4A2
Species	Homo sapiens
Entrez Gene ID	4929
Official Full Name	nuclear receptor subfamily 4 group A member 2
Also known as	NOT; RNR1; HZF-3; IDLDP; NURR1; TINUR
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000153234 MIM:601828; AllianceGenome:HGNC:7981
Map Location	2q24.1

Sample information of multiple sclerosis:

Detected Sample	peripheral whole blood
Sample Detail	N/A
Detected Method	RT-PCR
Disease	ALS
Disease subtype	fALS, sALS
Population	Caucasian
Sample Size	43 patients affected by ALS / 41 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	32188741
Year	2020
Title	The transcription factor Nurr1 is upregulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	The ALS group, comprising seven fALS and 36 sALS patients, showed higher Nurr1 mRNA levels compared with the HC group.Furthermore, there was a significant difference in age, but not in sex between ALS patients and HC.
Mechanism/Pathway	As neuroinflammation makes a central contribution to ALS pathogenesis, the identification of novel therapeutic targets acting on inflammation is considered mandatory.In this scenario, an interesting role is played by the nuclear receptor related 1 protein (Nurr1), also called NR4A2 (encoded by the gene NR4A2). Nurr1 is an orphan receptor belonging to the nuclear receptor subfamily 4 group A (NR4A) family.In the CNS, Nurr1 has a well-established role in the development and maintenance of midbrain dopaminergic (mDA) neurons. Indeed, Nurr1 has an anti-inflammatory role, inhibiting expression of the genes encoding pro-inflammatory components of the NFκB pathway in microglia and astrocytes.In addition to its role in the CNS, Nurr1 has an active role in PD, as downregulated levels of gene expression were also found in peripheral blood obtained from PD patients with progressive loss of mDA neurons.