Basic information of IL1R1 :
| Official Symbol of Gene | IL1R1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3554 |
| Official Full Name | interleukin 1 receptor type 1 |
| Also known as | P80; IL1R; IL1RA; CD121A; D2S1473; IL-1RT1; IL-1R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000115594 MIM:147810; AllianceGenome:HGNC:5993 |
| Map Location | 2q11.2-q12.1 |
Sample information of multiple sclerosis:
| Detected Sample | PBMC |
| Sample Detail | CD4+, CD4+CD45RA+ naive, and CD4+CD45RO+ memory T cells |
| Detected Method | qRT-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 6 RRMS patients / 6 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 27965670 |
| Year | 2016 |
| Title | Activated IL-1RI Signaling Pathway Induces Th17 Cell Differentiation via Interferon Regulatory Factor 4 Signaling in Patients with Relapsing-Remitting Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | IL-RI gene expression is significantly increased in both naive and memory CD4+ cells derived from RRMS patients in comparison to HCs. |
| Mechanism/Pathway | Interleukin-1 receptor signaling in T cells is required for the early programing of Th17 cell differentiation and Th17 cell-mediated autoimmunity.Th17 cells, which are characterized by the production of IL-17, are considered a key player in the pathogenesis of autoimmune diseases.IL-1R1 expression in T cells is necessary for the Th17 cell differentiation. |
