Basic information of MIR140 :
| Official Symbol of Gene | MIR140 |
| Species | Homo sapiens |
| Entrez Gene ID | 406932 |
| Official Full Name | microRNA 140 |
| Also known as | SEDN; MIRN140; mir-140; miRNA140 |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000208017 MIM:611894; miRBase:MI0000456; AllianceGenome:HGNC:31527 |
| Map Location | 16q22.1 |
Sample information of multiple sclerosis:
| Detected Sample | PBMCs |
| Sample Detail | N/A |
| Detected Method | qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 22 patients / 22 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 26780721 |
| Year | 2016 |
| Title | Inverse correlation of expression of microRNA-140-5p with progression of multiple sclerosis and differentiation of encephalitogenic T helper type 1 cells |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | The results showed that the expression level of miRâ€140â€5p was significantly downâ€regulated in both relapsing and remitting stages compared with that of the control. |
| Mechanism/Pathway | Our results indicated a negative correlation between the expression of miRâ€140â€5p and the development of the disease and suggested a possible role of miRâ€140â€5p in the differentiation of encephalitogenic CD4+ T cells. |
