Basic information of PTGDS :

Official Symbol of Gene	PTGDS
Species	Homo sapiens
Entrez Gene ID	5730
Official Full Name	prostaglandin D2 synthase
Also known as	PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000107317 MIM:176803; AllianceGenome:HGNC:9592
Map Location	9q34.3

Sample information of multiple sclerosis:

Detected Sample	fresh frozen blocks from MS brains, normal white matter
Sample Detail	N/A
Detected Method	RT-PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	5 MS patients / 3 non-MS subjects

Literature information of multiple sclerosis :

Pubmed ID	16409554
Year	2006
Title	Lipocalin-type prostaglandin D synthase (beta-trace) is upregulated in the alphaB-crystallin-positive oligodendrocytes and astrocytes in the chronic multiple sclerosis

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	The mRNA level of L-PGDS was increased 1.5- to 2-fold in MS white matter compared with the non-MS white matter. Its level was highest in the chronic plaque, followed by the shadow plaque and ANWM of MS brains.
Mechanism/Pathway	Prostaglandin (PG) D2 is a major PG in the central nervous system (CNS) and functions as a neuromodulator mediating the regulation of the sleep–wake cycle, body temperature, hormone release and pain responses. In the CNS, PGD2 is constitutively synthesized by lipocalin-type PGD synthase (L-PGDS), which is dominantly localized in leptomeningeal cells, and is secreted into the cerebrospinal fluid (CSF) as b-trace, a major protein in the human CSF.