Basic information of ERVW-1 :
| Official Symbol of Gene | ERVW-1 |
| Species | Homo sapiens |
| Entrez Gene ID | 30816 |
| Official Full Name | endogenous retrovirus group W member 1, envelope |
| Also known as | ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000242950 MIM:604659; AllianceGenome:HGNC:13525 |
| Map Location | 7q21.2 |
Sample information of multiple sclerosis:
| Detected Sample | brain tissue or cells |
| Sample Detail | N/A |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | RRMS, SPMS, RPMS |
| Population | N/A |
| Sample Size | 16 MS / 16 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 15452578 |
| Year | 2004 |
| Title | Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | HERV-W env mRNA expression was selectively upregulated in brain tissue from individuals with multiple sclerosis as compared with controls. |
| Mechanism/Pathway | Many human endogenous retroviruses (HERVs) have retained functional promoter, enhancer and polyadenylation signals, and these regulatory sequences have the potential to modify the expression of adjacent genes.An increase in the expression of HERV genes may be important in modulating host innate and adaptive immune responses with ensuing effects on the development of disease. |
