Basic information of SP3 :

Official Symbol of Gene	SP3
Species	Homo sapiens
Entrez Gene ID	6670
Official Full Name	Sp3 transcription factor
Also known as	SPR2
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000172845 MIM:601804; AllianceGenome:HGNC:11208
Map Location	2q31.1

Sample information of multiple sclerosis:

Detected Sample	PBMC
Sample Detail	N/A
Detected Method	Southern blot, PCR
Disease	MS
Disease subtype	RRMS, SPMS
Population	N/A
Sample Size	10 MS patients/ 8 healthycontrols

Literature information of multiple sclerosis :

Pubmed ID	10814800
Year	2000
Title	Localization of the human SP3 gene to chromosome 7p14-p15.2. The lack of expression in multiple sclerosis does not reflect abnormal gene organization

Results of multiple sclerosis :

Expression	No significance
Risk type	Disease risk
Result	Southern blot and polymerase chain reaction analysis of genomic DNA failed to demonstrate a detectable difference between MS and control PBMC.
Mechanism/Pathway	Sp3 belongs to a family of human transcription factors that bind GC/T box elements in order to either activate or repress transcription.MS is a putative autoimmune disease of the central nervous system (CNS) that exhibits both a genetic predisposition and evidence for an environmental infuence on susceptibility to the diseaseThe abnormal suppression of Sp3 expression in MS immune cells could well play a role in the control of the level of responsiveness of these cells.