Basic information of TIMP1 :
| Official Symbol of Gene | TIMP1 |
| Species | Homo sapiens |
| Entrez Gene ID | 7076 |
| Official Full Name | TIMP metallopeptidase inhibitor 1 |
| Also known as | EPA; EPO; HCI; CLGI; TIMP; TIMP-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000102265 MIM:305370; AllianceGenome:HGNC:11820 |
| Map Location | Xp11.3 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral venous puncture |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | CIS, RMS |
| Population | Caucasian |
| Sample Size | 222 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 24009164 |
| Year | 2014 |
| Title | Early detection of neutralizing antibodies to interferon-beta in multiple sclerosis patients: binding antibodies predict neutralizing antibody development |
Results of multiple sclerosis :
| Expression | No significance |
| Risk type | Treatment risk |
| Result | TIMP-1 values did not differ between the NAb-positive and NAb-negative treated patient groups at any time point. |
| Mechanism/Pathway | We investigated several molecules which are involved in the mechanisms of action of IFN-b and can be easily determined in serum: MMP-9 and its antagonist tissue-inhibitor of matrix metalloproteinase-1 (TIMP-1), which regulate leukocyte trafficking across the blood-brain barrier. |
