Basic information of TNFSF10 :
| Official Symbol of Gene | TNFSF10 |
| Species | Homo sapiens |
| Entrez Gene ID | 8743 |
| Official Full Name | TNF superfamily member 10 |
| Also known as | TL2; APO2L; CD253; TANCR; TRAIL; Apo-2L; TNLG6A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000121858 MIM:603598; AllianceGenome:HGNC:11925 |
| Map Location | 3q26.31 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral venous puncture |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | CIS, RMS |
| Population | Caucasian |
| Sample Size | 222 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 24009164 |
| Year | 2014 |
| Title | Early detection of neutralizing antibodies to interferon-beta in multiple sclerosis patients: binding antibodies predict neutralizing antibody development |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Treatment risk |
| Result | Concentrations of sTRAIL was significantly lower in the BAb-positive than BAb-negative group. |
| Mechanism/Pathway | We investigated several molecules which are involved in the mechanisms of action of IFN-b and can be easily determined in serum: soluble tumor necrosis factorrelated apoptosis-inducing ligand (sTRAIL), which is shown to inhibit autoreactive and antigen-specific T cells. |
