Basic information of TYRO3 :

Official Symbol of Gene	TYRO3
Species	Homo sapiens
Entrez Gene ID	7301
Official Full Name	TYRO3 protein tyrosine kinase
Also known as	BYK; Dtk; RSE; Rek; Sky; Tif; Etk-2
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000092445 MIM:600341; AllianceGenome:HGNC:12446
Map Location	15q15.1

Sample information of multiple sclerosis:

Detected Sample	PBMC
Sample Detail	N/A
Detected Method	qPCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	29 MS patients / 31 healthy volunteers

Literature information of multiple sclerosis :

Pubmed ID	33347509
Year	2002
Title	GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection

Results of multiple sclerosis :

Expression	down-regulation
Risk type	Disease risk
Result	We have found a significantly lower percentage of monocytes and DCs expressing TYRO3 in patients with MS compared to HC groups.The mean expression level of TYRO3 per cell did not show statistical differences in monocytes, but this receptor showed a significantly higher level in DCs of HC compared to MS.
Mechanism/Pathway	Considering the critical role of negative regulatory pathways in avoiding chronic inflammation and autoimmunity, we focus on a subfamily of receptor tyrosine kinases (TKR) that involves TYRO3.This receptor showed a preponderant role in innate immune response and their genetic ablation leads to an impaired immune response with exacerbated autoimmune features.The engagement of this receptor by its ligands, PROS1 and GAS6, limit the magnitude and time course of the inflammatory response that can ensure a return to the baseline.