Basic information of CCR5 :

Official Symbol of Gene	CCR5
Species	Homo sapiens
Entrez Gene ID	1234
Official Full Name	C-C motif chemokine receptor 5
Also known as	CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000160791 MIM:601373; AllianceGenome:HGNC:1606
Map Location	3p21.31

Sample information of multiple sclerosis:

Detected Sample	heparinized venous blood
Sample Detail	N/A
Detected Method	flow cytometry
Disease	MS
Disease subtype	RRMS
Population	Caucasian
Sample Size	108 MS patients / 42 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	17511851
Year	2007
Title	Chemokine receptor CCR5 in interferon-treated multiple sclerosis

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	We found a higher percentage of CCR5-positive monocytes in patients than in healthy controls. Increased monocyte expression of CCR5 correlated weakly with an increased short-term relapse risk.
Mechanism/Pathway	Multiple sclerosis (MS) is characterized by T cell and monocyte infiltration in the central nervous system.The CC chemokine receptor CCR5 has been implicated in the pathogenesis of MS as mononuclear cells.