Basic information of RORA :
| Official Symbol of Gene | RORA |
| Species | Homo sapiens |
| Entrez Gene ID | 6095 |
| Official Full Name | RAR related orphan receptor A |
| Also known as | ROR1; ROR2; ROR3; RZRA; NR1F1; RORa1; IDDECA; RORalpha; RZR-ALPHA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000069667 MIM:600825; AllianceGenome:HGNC:10258 |
| Map Location | 15q22.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqMan Quantitative Real-Time PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 50 RRMS patients treated with IFN-β / 50 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 29889063 |
| Year | 2018 |
| Title | Down-regulation of RORA gene expression in the blood of multiple sclerosis patients |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Treatment risk |
| Result | We found that RORA expression was significantly down-regulated in MS patients compared with controls. |
| Mechanism/Pathway | RORA is induced by activation of the STAT3 pathway by IL-6 and is expressed in Th17 cells and promotes Th17 differentiation.In downstream of STAT3, ROR α and ROR γ synergically mediate Th17 differentiation and IL-17A production.IL-17A have protective roles in host defense and inflammatory diseases.In addition,IL-17 family cytokines are involved in many autoimmune diseases including rheumatoid arthritis (RA), inflammatory bowel disease and MS. |
