Basic information of OMG :

Official Symbol of Gene	OMG
Species	Homo sapiens
Entrez Gene ID	4974
Official Full Name	oligodendrocyte myelin glycoprotein
Also known as	OMGP
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000126861 MIM:164345; AllianceGenome:HGNC:8135
Map Location	17q11.2

Sample information of multiple sclerosis:

Detected Sample	white blood cells
Sample Detail	N/A
Detected Method	microsatellites and “hot-start” polymerase chain reaction (PCR) amplifications
Disease	MS
Disease subtype	N/A
Population	Caucasian and European
Sample Size	65 multiplex MS families consisting of 169 affected with MS and 102 affected sibpairs

Literature information of multiple sclerosis :

Pubmed ID	10541588
Year	1999
Title	Linkage analysis of candidate myelin genes in familial multiple sclerosis

Results of multiple sclerosis :

Expression	No significance
Risk type	Disease risk
Result	Results indicate that OMGP gene do not have a significant genetic effect on susceptibility to MS in this population.
Mechanism/Pathway	Myelin proteins that have been investigated as possible target antigens of the autoimmune response in MS and MS-like disorders.In addition to the immune-mediated component of MS, an underlying complex genetic susceptibility is a significant contributing factor.Because myelin appears to be a target for the autoimmune attack in MS, genes coding for myelin proteins are potential candidates for involvement in the pathogenesis of MS. Polymorphisms or mutations in coding or regulatory sequences of these genes could hypothetically promote autoimmunity if they modify the expression, turnover, or function of myelin proteins.