Basic information of VRK2 :

Official Symbol of Gene	VRK2
Species	Homo sapiens
Entrez Gene ID	7444
Official Full Name	VRK serine/threonine kinase 2
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000028116 MIM:602169; AllianceGenome:HGNC:12719
Map Location	2p16.1

Sample information of multiple sclerosis:

Detected Sample	PBMC
Sample Detail	N/A
Detected Method	RT-PCR
Disease	MS
Disease subtype	RRMS
Population	N/A
Sample Size	50 MS patients / 50 healthy individuals

Literature information of multiple sclerosis :

Pubmed ID	29100046
Year	2017
Title	Vaccinia Related Kinase 2 (VRK2) expression in neurological disorders: schizophrenia, epilepsy and multiple sclerosis

Results of multiple sclerosis :

Expression	down-regulation
Risk type	Disease risk
Result	The result demonstrates that VRK2 gene expression decreased in MS patients as compared with controls.
Mechanism/Pathway	Inflammation is considered as the first step in the pathophysiology of MS, although initiation mechanism is not well understood.There is increasing recognition that the disturbance of blood brain barrier (BBB) permeability and apoptosis pathway are associated with MS etiology.The Vaccinia Related Kinase 2 (VRK2) gene is located in 2p16.1 chromosomal region.VRK2 codes for a serine threonine kinase of the casein kinase 1 group.It has 9 transcripts due to alternative splicing and expressed in many tissues such as brain and blood.VRK2 participates in apoptosis regulating signaling pathways, immune responses, tumor cell growth, brain volume and structure.Due to the involvement of VRK2 gene in apoptotic pathway and apoptosis dysregulation in MS patients, it is most probable that it plays a regulating role in MS.