Basic information of NLRP3 :
| Official Symbol of Gene | NLRP3 |
| Species | Homo sapiens |
| Entrez Gene ID | 114548 |
| Official Full Name | NLR family pyrin domain containing 3 |
| Also known as | AII; AVP; FCU; MWS; FCAS; KEFH; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; DFNA34; PYPAF1; AGTAVPRL |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000162711 MIM:606416; AllianceGenome:HGNC:16400 |
| Map Location | 1q44 |
Sample information of multiple sclerosis:
| Detected Sample | PBMC |
| Sample Detail | N/A |
| Detected Method | qRT-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 18 RRMS patients / 21 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 25458313 |
| Year | 2015 |
| Title | Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | NLRP3 mRNA level was significantly higher in RRMS patients compared to HC. |
| Mechanism/Pathway | In addition to IL-1β,the NLRP3 inflammasome also processes IL-18, which is another pro-inflammatory cytokine.Inflammasome activation is crucial for host defence to pathogens. An increased NLRP3 inflammasome activity might be important in the induction of pathogenic Th17 cells in MS patients. |
