Basic information of CASP1 :
| Official Symbol of Gene | CASP1 |
| Species | Homo sapiens |
| Entrez Gene ID | 834 |
| Official Full Name | caspase 1 |
| Also known as | ICE; P45; IL1BC |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000137752 MIM:147678; AllianceGenome:HGNC:1499 |
| Map Location | 11q22.3 |
Sample information of multiple sclerosis:
| Detected Sample | PBMC |
| Sample Detail | N/A |
| Detected Method | qRT-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 18 RRMS patients / 21 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 25458313 |
| Year | 2015 |
| Title | Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | caspase-1 mRNA level was significantly higher in RRMS patients compared to HC. |
| Mechanism/Pathway | Pathogenic Th17 cells can be induced by a cytokine cocktail containing IL-1β, which is a potent pro-inflammatory cytokine.Upon inflammasome activation, the NLRP3 protein recruits the inflammasome adaptor protein apoptosis-associated speck-like protein containing C-terminal caspase recruitment domain (ASC), which in turn interacts with pro-caspase-1 leading to its cleavage and activation.Finally, the active caspase-1 processes pro-IL-1β into its mature form. |
