Basic information of ERVW-1 :
| Official Symbol of Gene | ERVW-1 |
| Species | Homo sapiens |
| Entrez Gene ID | 30816 |
| Official Full Name | endogenous retrovirus group W member 1, envelope |
| Also known as | ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000242950 MIM:604659; AllianceGenome:HGNC:13525 |
| Map Location | 7q21.2 |
Sample information of multiple sclerosis:
| Detected Sample | total blood |
| Sample Detail | N/A |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | RRMS, PPMS, SPMS |
| Population | Caucasian |
| Sample Size | 22 MS patients / 22 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 30740110 |
| Year | 2019 |
| Title | Do Antiretroviral Drugs Protect From Multiple Sclerosis by Inhibiting Expression of MS-Associated Retrovirus? |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | The expression of MSRV/HERV-Wenv in the MS group was significantly higher compared with HC. |
| Mechanism/Pathway | Activation of autoimmune processes in MS results from the interaction of genetic and environmental factors.An additional risk factor that has been identified is the expression of human endogenous retroviruses (HERVs) of the HERV-W family. |
