Basic information of YAP1 :
| Official Symbol of Gene | YAP1 |
| Species | Homo sapiens |
| Entrez Gene ID | 10413 |
| Official Full Name | Yes1 associated transcriptional regulator |
| Also known as | YAP; YKI; COB1; YAP2; YAP-1; YAP65 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000137693 MIM:606608; AllianceGenome:HGNC:16262 |
| Map Location | 11q22.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | qPCR |
| Disease | MS |
| Disease subtype | RRMS,SPMS |
| Population | N/A |
| Sample Size | 72 MS patients(35 sporadic,37 familial MS patients)/74 controls(34 healthy first-degree relatives of the familial MS patients (HFR),40 healthy individuals ) |
Literature information of multiple sclerosis :
| Pubmed ID | 33833274 |
| Year | 2021 |
| Title | Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | The familial and sporadic patients displayed a significantly lower level of expression of YAP1 in comparison to the HFR group. |
| Mechanism/Pathway | The Hippo pathway is an important mediator of myelination in the nervous system and might contribute to the pathophysiology of MS. YAP1 is the key effector of the Hippo pathway. |
