Basic information of WWTR1 :
| Official Symbol of Gene | WWTR1 |
| Species | Homo sapiens |
| Entrez Gene ID | 25937 |
| Official Full Name | WW domain containing transcription regulator 1 |
| Also known as | TAZ |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000018408 MIM:607392; AllianceGenome:HGNC:24042 |
| Map Location | 3q25.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | qPCR |
| Disease | MS |
| Disease subtype | RRMS,SPMS |
| Population | N/A |
| Sample Size | 72 MS patients(35 sporadic,37 familial MS patients)/74 controls(34 healthy first-degree relatives of the familial MS patients (HFR),40 healthy individuals ) |
Literature information of multiple sclerosis :
| Pubmed ID | 33833274 |
| Year | 2021 |
| Title | Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | There was also an increased expression of TAZ in the familial and HFR groups, as compared to the control group. |
| Mechanism/Pathway | The Hippo pathway is an important mediator of myelination in the nervous system and might contribute to the pathophysiology of MS.TAZ is the key effector of the Hippo pathway. |
