Basic information of CRB3 :

Official Symbol of Gene	CRB3
Species	Homo sapiens
Entrez Gene ID	92359
Official Full Name	crumbs cell polarity complex component 3
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000130545 MIM:609737; AllianceGenome:HGNC:20237
Map Location	19p13.3

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	N/A
Detected Method	qPCR
Disease	MS
Disease subtype	RRMS,SPMS
Population	N/A
Sample Size	72 MS patients(35 sporadic,37 familial MS patients)/74 controls(34 healthy first-degree relatives of the familial MS patients (HFR),40 healthy individuals )

Literature information of multiple sclerosis :

Pubmed ID	33833274
Year	2021
Title	Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	The increased expression level in the sporadic patients and control group, as compared to the HFR group, was seen in CRB3.
Mechanism/Pathway	The Hippo pathway is an important mediator of myelination in the nervous system and might contribute to the pathophysiology of MS. CRB3 is the key effector of the Hippo pathway.