Basic information of ERVW-1 :
| Official Symbol of Gene | ERVW-1 |
| Species | Homo sapiens |
| Entrez Gene ID | 30816 |
| Official Full Name | endogenous retrovirus group W member 1, envelope |
| Also known as | ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000242950 MIM:604659; AllianceGenome:HGNC:13525 |
| Map Location | 7q21.2 |
Sample information of multiple sclerosis:
| Detected Sample | CSF and plasma |
| Sample Detail | N/A |
| Detected Method | Real-time PCR |
| Disease | MS |
| Disease subtype | RRMS,SPMS,RRMS |
| Population | N/A |
| Sample Size | 38 MS patients / 40 non-MS |
Literature information of multiple sclerosis :
| Pubmed ID | 17961112 |
| Year | 2007 |
| Title | Comparative expression of human endogenous retrovirus-W genes in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | ERVWE1 env-encoding DNA and RNA exhibited increased detection and expression in the brains of MS patients,while comparable changes in MSRV abundance were not observed. |
| Mechanism/Pathway | A member of the HERV-W family for which a full length sequence encoding gag, pol, and env sequences is located on chromosome 7q (ERVWE1), and its env-encoded protein, syncytin-1, has been implicated in the neuroinflammatory cascade underlying MS pathogenesis,perhaps by affecting mitochondrial function in astrocytes. |
