Basic information of ERVW-1 :
| Official Symbol of Gene | ERVW-1 |
| Species | Homo sapiens |
| Entrez Gene ID | 30816 |
| Official Full Name | endogenous retrovirus group W member 1, envelope |
| Also known as | ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000242950 MIM:604659; AllianceGenome:HGNC:13525 |
| Map Location | 7q21.2 |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | frontal white matter |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | PPMS,SPMS,RRMS |
| Population | N/A |
| Sample Size | 19 MS / 20 non-MS |
Literature information of multiple sclerosis :
| Pubmed ID | 17209768 |
| Year | 2006 |
| Title | Quantitative analysis of human endogenous retrovirus-W env in neuroinflammatory diseases |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Syncytin-1 mRNA exhibited higher levels in MS brains compared to non-MS brains,while the other HERV envs did not exhibit differences between clinical groups.Median syncytin-1 RNA copy numbers were significantly increased in MS brains compared to non-MS brains per/g RNA . |
| Mechanism/Pathway | N/A |
