Basic information of VEGFA :
| Official Symbol of Gene | VEGFA |
| Species | Homo sapiens |
| Entrez Gene ID | 7422 |
| Official Full Name | vascular endothelial growth factor A |
| Also known as | vascular endothelial growth factor A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000112715 MIM:192240; AllianceGenome:HGNC:12680 |
| Map Location | 6p21.1 |
Sample information of multiple sclerosis:
| Detected Sample | fresh blood |
| Sample Detail | N/A |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | SPMS,RRMS,PPMS |
| Population | N/A |
| Sample Size | 60 MS/20HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 25887968 |
| Year | 2016 |
| Title | Vascular endothelial growth factor-A mRNA gene expression in clinical phases of multiple sclerosis |
Results of multiple sclerosis :
| Expression | no significance |
| Risk type | Phenotypic risk |
| Result | There was no correlation between vascular endothelial growth factor A gene expression levels and duration of disease, multiple sclerosis progression index or expanded disability status scale. |
| Mechanism/Pathway | There is substantial evidence that VEGF-A is a pro-inflammatory factor and can cause CNS damage.Inhibition of endogenous VEGF-A can lead to decreased brain lesion size, whereas administration of VEGF-A can exacerbate CNS damage and up-regulate immunomodulatory adhesion molecules and cytokines. |
