Basic information of ERVW-1 :
| Official Symbol of Gene | ERVW-1 |
| Species | Homo sapiens |
| Entrez Gene ID | 30816 |
| Official Full Name | endogenous retrovirus group W member 1, envelope |
| Also known as | ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000242950 MIM:604659; AllianceGenome:HGNC:13525 |
| Map Location | 7q21.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood lymphocytes,serum |
| Sample Detail | N/A |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 32 MS/ 81 controls(17 myasthenia gravis patients, 16 Parkinson’s disease patients, 21 migraine patients, 27 healthy adults) |
Literature information of multiple sclerosis :
| Pubmed ID | 12587074 |
| Year | 2003 |
| Title | Multiple sclerosis-associated virus-related pol sequences found both in multiple sclerosis and healthy donors are more frequently expressed in multiple sclerosis patients |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | More frequent expression of MSRV sequences detected in lymphocytes RNA (cDNA), as well as their presence in higher frequency in the serum of MS patients. |
| Mechanism/Pathway | There is much evidence that strongly indicates autoimmune response, in which viral infection plays a crucial role in the pathogenesis of MS. |
