Basic information of MX1 :
| Official Symbol of Gene | MX1 |
| Species | Homo sapiens |
| Entrez Gene ID | 4599 |
| Official Full Name | MX dynamin like GTPase 1 |
| Also known as | MX; MxA; IFI78; IFI-78K; lncMX1-215 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000157601 MIM:147150; AllianceGenome:HGNC:7532 |
| Map Location | 21q22.3 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | quantitative real time-PCR |
| Disease | MS |
| Disease subtype | RRMA |
| Population | Iranian |
| Sample Size | 50 RRMS patients / 50 normal controls |
Literature information of multiple sclerosis :
| Pubmed ID | 28417621 |
| Year | 2017 |
| Title | Inverse Relation between MxA Gene Expression and Age in Multiple Sclerosis Patients Reveals a Gender Difference in Response to Interferon Therapy |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | The levels of gene expression were decreased in RRMS patients compared with normal counterparts.This decrease was significant in females compared to males. |
| Mechanism/Pathway | MxAcan inhibit the replication of single-strand RNA viruses, and is stable in the absence of viral infections.25In addition;MxA has a possible role in the signal transduction of the apoptotic pathway. |
