Basic information of IL21 :
| Official Symbol of Gene | IL21 |
| Species | Homo sapiens |
| Entrez Gene ID | 59067 |
| Official Full Name | interleukin 21 |
| Also known as | Za11; IL-21; CVID11 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000138684 MIM:605384; AllianceGenome:HGNC:6005 |
| Map Location | 4q27 |
Sample information of multiple sclerosis:
| Detected Sample | serum |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iraqi |
| Sample Size | 70 MS / 50 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 35891764 |
| Year | 2022 |
| Title | Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | no significant |
| Risk type | Disease risk |
| Result | There was a slight increase in IL-21 serum levels in MS patients, compared to the controls; however, it was not significantly different. |
| Mechanism/Pathway | B-cell proliferation is induced by IL-21, which improves their function by increasing antibody production and reducing cell death. It is also been linked to controlling antibody development and preventing apoptosis and plasma cell differentiation. The cluster of differentiation 81 T cells, NK cells, and NK T cells are activated by IL-21, which enhances their cytotoxic activity and proliferation. |
