Basic information of CFH :
| Official Symbol of Gene | CFH |
| Species | Homo sapiens |
| Entrez Gene ID | 3075 |
| Official Full Name | complement factor H |
| Also known as | FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000000971 MIM:134370; AllianceGenome:HGNC:4883 |
| Map Location | 1q31.3 |
Sample information of multiple sclerosis:
| Detected Sample | venous blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS, SPMS,RPMS |
| Population | N/A |
| Sample Size | 42 MS / 34 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 26186240 |
| Year | 2015 |
| Title | Serum complement factor H and Tyr402 His gene polymorphism among Egyptians with multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | There was a significant difference in serum CFH levels between the MS and HC groups.Serum CFH level was significantly lower in HC subjects than in each of RRMS, PPMS, SPMS and RPMS subgroups of the MS patients. |
| Mechanism/Pathway | Serum CFH is the major fluid-phase regulator of the alternative pathway of C, increasingly recognised as a critical player in many diseases. |
