Basic information of MIF :
| Official Symbol of Gene | MIF |
| Species | Homo sapiens |
| Entrez Gene ID | 4282 |
| Official Full Name | macrophage migration inhibitory factor |
| Also known as | GIF; GLIF; MMIF |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000240972 MIM:153620; AllianceGenome:HGNC:7097 |
| Map Location | 22q11.23 |
Sample information of multiple sclerosis:
| Detected Sample | plasma |
| Sample Detail | N/A |
| Detected Method | Real-Time PCR |
| Disease | MS |
| Disease subtype | CIS-MS,RRMS,PPMS,SPMS |
| Population | Male |
| Sample Size | 14 CIS,55 RRMS / 64 SPMS+PPMS / 49 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 28923927 |
| Year | 2017 |
| Title | MIF and D-DT are potential disease severity modifiers in male MS subjects |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Phenotypic risk |
| Result | MIF plasma levels were significantly higher in male progressive MS subjects compared with CIS or RRMS subjects, but only nominally higher compared with HC. |
| Mechanism/Pathway | MIF was one of the first cytokines to be described and is a key mediator of many autoimmune inflammatory diseases.It was suggested that MIF contributes to the pathogenesis of EAE/MS by promoting leukocyte recruitment into the CNS, inhibiting apoptosis of activated monocytes, and enhancing the secretion of proinflammatory cytokines. |
