Basic information of CXCL12 :
| Official Symbol of Gene | CXCL12 |
| Species | Homo sapiens |
| Entrez Gene ID | 6387 |
| Official Full Name | C-X-C motif chemokine ligand 12 |
| Also known as | IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000107562 MIM:600835; AllianceGenome:HGNC:10672 |
| Map Location | 10q11.21 |
Sample information of multiple sclerosis:
| Detected Sample | serum |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 100 MS patients / 100 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 22125123 |
| Year | 2011 |
| Title | The SDF-1 3'a genetic variation of the chemokine SDF-1α (CXCL12) in parallel with its increased circulating levels is associated with susceptibility to MS: a study on Iranian multiple sclerosis patients |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Our results showed that serum levels of SDF-1α (CXCL12) were markedly higher in patients than healthy controls. |
| Mechanism/Pathway | Immune regulatory factors might influence the pathogenesis of MS. Chemokines are low molecular weight proteins. A chemokine network exists in the CNS which is involved in physiological responses, under certain circumstances, pathological and repair processes subsequent to neurological injury.CXCL12 axis plays a significant role in hematopoiesis including hematopoietic cell differentiation and survival and homing of hematopoietic progenitors to the bone marrow and regulation of neuronal progenitor cell migration in the CNS. |
