Basic information of WFDC21P :
| Official Symbol of Gene | WFDC21P |
| Species | Homo sapiens |
| Entrez Gene ID | 645638 |
| Official Full Name | WAP four-disulfide core domain 21, pseudogene |
| Also known as | LNCDC; lnc-DC; linc-DC |
| Gene Type | pseudo |
| dbXrefs | Ensembl:ENSG00000261040 MIM:615772; AllianceGenome:HGNC:50357 |
| Map Location | 17q23.1 |
Sample information of multiple sclerosis:
| Detected Sample | serum |
| Sample Detail | N/A |
| Detected Method | qRT-PCR |
| Disease | MS |
| Disease subtype | RRMS,SPMS |
| Population | Egyptian |
| Sample Size | 45 MS patients / 45 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 30514825 |
| Year | 2019 |
| Title | LncRNAs, MALAT1 and lnc-DC as potential biomarkers for multiple sclerosis diagnosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Phenotypic risk |
| Result | Concerning the serum level of lnc-DC, it was elevated significantly in RRMS patients compared with healthy subjects.Meanwhile, no significant difference between SPMS subgroup and healthy subjects regarding the level of lnc-DC. |
| Mechanism/Pathway | lnc-DC is a long non-coding RNA that was found to be expressed in dendritic cells (DCs) and could mediate DCs maturation by phosphorylating transducer and activator of transcription 3 (STAT3). It was found that lnc-DC can affect the differentiation of monocytes into DCs that induce T-cell activation through its role in the transcription of downstream genes. So, lnc-DC can induce the differentiation and maturation of DCs. |
