Basic information of MIRLET7F1 :

Official Symbol of Gene	MIRLET7F1
Species	Homo sapiens
Entrez Gene ID	406888
Official Full Name	microRNA let-7f-1
Also known as	LET7F1; let-7f-1; MIRNLET7F1
Gene Type	ncRNA
dbXrefs	Ensembl:ENSG00000199072 MIM:612146; miRBase:MI0000067; AllianceGenome:HGNC:31483
Map Location	9q22.32

Sample information of multiple sclerosis:

Detected Sample	PBMCs
Sample Detail	N/A
Detected Method	qRT-PCR
Disease	MS
Disease subtype	RRMS
Population	N/A
Sample Size	10 MS patients / 10 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	22272099
Year	2011
Title	Genetic association and altered gene expression of mir-155 in multiple sclerosis patients

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	Monitoring for differences in expression levels between cases and controls showed a significant up-regulation of let-7f.
Mechanism/Pathway	MicroRNAs (miRNAs) are a class of short single-stranded non-coding RNAs that modulate the expression of multiple target mRNAs by inducing either translational repression or mRNA degradation.MiRNAs have emerged as key post-transcriptional regulators of diverse biological processes, and mounting evidence point to miRNAs as critical players not only for the development of the immune system, but also for the correct function of both its innate and adaptive branches. Considering that miRNAs are stringently regulated in immune cells to maintain immune homoeostasis, it is conceivable that dysregulation of miRNA expression levels can determine an immune-tolerance breakdown and, therefore, the development of autoimmunity.