Basic information of IL7R :
| Official Symbol of Gene | IL7R |
| Species | Homo sapiens |
| Entrez Gene ID | 3575 |
| Official Full Name | interleukin 7 receptor |
| Also known as | ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024 |
| Map Location | 5p13.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | Real-time PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | N/A |
| Sample Size | 72 MS patients / 74 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 34584155 |
| Year | 2021 |
| Title | Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis |
Results of multiple sclerosis :
| Expression | No significance |
| Risk type | Disease risk |
| Result | We did not observe a significant difference in expression between the familial patients and healthy individuals (both Control and FDR). |
| Mechanism/Pathway | IL7 has a range of biological activities and is essential for the survival, proliferation, and homeostasis of T-cells.It is also a factor in bone marrow culture that can induce the proliferation of B progenitor cells.IL7R may also have a primary signaling function through the autoimmunity cascade.This gene may also be involved in the remyelination process.Deletion of IL7R delays the maturation and differentiation of oligodendrocyte cells. |
