Basic information of NFATc2 :
| Official Symbol of Gene | NFATc2 |
| Species | Homo sapiens |
| Entrez Gene ID | 4773 |
| Official Full Name | nuclear factor of activated T cells 2 |
| Also known as | JCOSL; NFAT1; NFATP |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000101096 MIM:600490; AllianceGenome:HGNC:7776 |
| Map Location | 20q13.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | Real-time PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | N/A |
| Sample Size | 72 MS patients / 74 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 34584155 |
| Year | 2021 |
| Title | Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | There was an increased NFATc2 expression level in MS patients versus healthy controls. |
| Mechanism/Pathway | Wnt proteins have been shown to regulate T-cell growth and maturation of dendritic cells and also play a significant function in the expression of inflammatory mediators.NFATc2 is one of the important genes within the Wnt signaling pathway that plays an important role in immune system inflammation. It is one of the several transcription factors regulated by Calcineurin in the Wnt/Ca2+ signaling pathway.NFATc2 also mediates oligodendrocyte differentiation, T-cell function and coordinates the induction of cytokines and immunomodulatory molecules. |
