Basic information of THRIL :
| Official Symbol of Gene | THRIL |
| Species | Homo sapiens |
| Entrez Gene ID | 102659353 |
| Official Full Name | TNF and HNRNPL related immunoregulatory long non-coding RNA |
| Also known as | Linc1992; BRI3BPAS1; BRI3BP-AS1; TCONS_00020260 |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000280634 MIM:615622; AllianceGenome:HGNC:49503 |
| Map Location | 12q24.31 |
Sample information of multiple sclerosis:
| Detected Sample | PBMCs |
| Sample Detail | N/A |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Iranian |
| Sample Size | 51 MS patients / 51 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 31713760 |
| Year | 2019 |
| Title | Differential expression of STAT3 gene and its regulatory long non-coding RNAs, namely lnc-DC and THRIL, in two eastern Iranian ethnicities with multiple sclerosis |
Results of multiple sclerosis :
| Expression | N/A |
| Risk type | Disease risk |
| Result | The expression level of THRIL significantly increased in the North Khorasan MS patients while this lncRNA downregulated in the Sistani MS patients in comparison with their respective healthy controls. |
| Mechanism/Pathway | Another regulatory long non-coding RNA which has a contributing role to the inflammatory conditions is THRIL that regulates TNFα expression through the interaction with hnRNPL (heterogeneous nuclear ribonucleoprotein L).TNFα is a potent inhibitor of STAT3 activation in human monocyte-derived macrophages. |
